Due to an immense variety of applications with multiple combinations of different individual steps, domino reactions have proven themselves as efficient and economical methods but also as an elegant concept in organic syntheses. The fact that the newly created stereocenters are highly-substituted, tertiary or quaternary ones, makes the methods that are presented in this review useful and versatile tools in synthesis.ĭomino reactions are defined as chemical transformations that involve the formation of two ore more bonds under the same conditions in a consecutive manner, the functionality of the preceding step inducing the bond formation of the subsequent one. Enantioselective protocols were developed only recently. The diastereoselective versions permit the formation of multiple stereocenters in mono- and polycycles. Valuable protocols lead to – otherwise not easily accomplished – stereo control in the formation of tri- and tetra-substituted double bonds according to the first conception. Secondly as diastereoselective and thirdly enantioselective formation of stereogenic carbon centers when the intramolecular Heck step is directed to an alkene moiety. The stereochemistry of this cascade is concerned under three aspects: Firstly, as stereoselective formation of carbon−carbon-double bonds, when the initial carbometalation occurs at an alkyne moiety. Palladium catalysis enables efficient and versatile domino reactions that are initiated by an intramolecular Mizoroki-Heck reaction and then terminated by a Suzuki-Miyaura coupling.
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